Oxygen sensing, homeostasis, and disease.
نویسنده
چکیده
From the Vascular Program, Institute for Cell Engineering; the Departments of Pediatrics, Medicine, Oncology, Radiation Oncology, and Biological Chemistry; and the McKusick–Nathans Institute of Genetic Medicine — all at the Johns Hopkins University School of Medicine, Baltimore. Address reprint requests to Dr. Semenza at Broadway Research Bldg., Suite 671, 733 N. Broadway, Baltimore, MD 21205, or at [email protected].
منابع مشابه
The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease.
The ability to sense and respond to changes in oxygen is essential for the survival of prokaryotic and eukaryotic organisms. Oxygen-sensing mechanisms have been developed to maintain cell and tissue homeostasis, as well as to adapt to the chronic low-oxygen conditions found in diseases such as cancer. This report on the first Keystone Meeting on the Biology of Hypoxia will summarize our current...
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The discovery of carotid bodies as sensory receptors for detecting arterial blood oxygen levels, and the identification and elucidation of the roles of hypoxia-inducible factors (HIFs) in oxygen homeostasis have propelled the field of oxygen biology. This review highlights the gas-messenger signaling mechanisms associated with oxygen sensing, as well as transcriptional and non-transcriptional m...
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Oxygen plays a critical role in the perpetuation and propagation of almost all forms of life. The primary site of cellular oxygen consumption is the mitochondrial electron transport chain and in addition, oxygen is also used as a substrate for various enzymes involved in cellular homeostasis. Although our knowledge of the biochemistry and physiology of oxygen transport is century old, recent de...
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The bone microenvironment is composed of niches that house cells across variable oxygen tensions. However, the contribution of oxygen gradients in regulating bone and blood homeostasis remains unknown. Here, we generated mice with either single or combined genetic inactivation of the critical oxygen-sensing prolyl hydroxylase (PHD) enzymes (PHD1-3) in osteoprogenitors. Hypoxia-inducible factor ...
متن کاملInvited Review HIGHLIGHTED TOPIC Oxygen Sensing in Health and Disease Peripheral chemoreceptors in health and disease
Prabhakar, Nanduri R., and Ying-Jie Peng. Peripheral chemoreceptors in health and disease. J Appl Physiol 96: 359–366, 2004; 10.1152/japplphysiol. 00809.2003.—Peripheral chemoreceptors (carotid and aortic bodies) detect changes in arterial blood oxygen and initiate reflexes that are important for maintaining homeostasis during hypoxemia. This mini-review summarizes the importance of peripheral ...
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ورودعنوان ژورنال:
- The New England journal of medicine
دوره 365 6 شماره
صفحات -
تاریخ انتشار 2011